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 Technology Information 
TitleArtificial Heart Valve and Methods & Devices for its Implantation
Case Number417
AbstractName of the inventor: Marc Bessler MD

STV Reference: IR# 416, 417


Brief Description:
This patented technology provides a design for an artificial heart valve and methods for minimally invasive valve delivery and placement. The valve possesses unique, function-enhancing features. Specifically, the device is a collapsible bioprosthetic valve mounted on a stent that can be compressed to a low profile for percutaneous delivery and placement.

The valve has certain distinguishing aspects: Firstly, the valve features a perivascular cuff element that forms a tight seal against the aorta. It comprises a circular portion of leaflets extending from the periphery of towards the center, with the leaflets being configured to allow for flow of blood through the valve in one direction only. Secondly, the device is self expanding. The valve is attached to a self expanding stent element with valve properties that also permit flow in only one direction. The stent can have anchoring barbs to hold it in place near the disease site. A cutting mechanism is used to excise the diseased tissues and place the valve.

Prototype valves have been built and tested in animals.

Valve Replacement Market:
Over 100,000 valve replacement procedures are performed in the U.S. each year, for total revenues of $519 million in 2005. Almost 70% of these revenues ($360 million) are derived from tissue heart valve replacements. It is estimated that by 2012, the tissue valve replacement market will reach $645 million. The majority of valve replacements are performed for aortic valves. (Frost & Sullivan, 2006)

Potential Advantages:
- Self-expanding capabilities of device may eliminate the need for use of balloon catheter
- Perivascular cuff provides a tight seal against aorta avoiding thrombogenicity, leakage
- Ease of placement may permit positioning of valve during beating heart procedures
- Mechanical valve more than tissue valve technologies
- Minimally invasive procedure -- less stress to patient, would reduce hospital stay time and cost of heart valve replacement up to $50,000 per procedure


TaxonomyCardiovascular
Medical & Surgical Devices
Surgical/Medical Devices
Keywordscatheter, stent, heart valve, endovascular, transluminal, femoral artery, pre02 licORpatMinusNYSPI, AAH5set
 Licensing Contact 
The responsible technology licensing officer is Donna See but for more information on this technology, please contact stvinfo@columbia.edu .
 Web Links 
Name Description Open Link
Patent number: US5855601 Issued patent Click Here

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