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Technology Information
Title
Compounds which prevent neuronal cell death & uses thereof
Case Number
535
Abstract
Name of the inventor: Carol M. Troy MD, PhD
A method of inhibiting cell death and for alleviating symptoms of a neurodegenerative disorder in a subject is described.
The method involves inhibition of enzyme activity on a substrate in a cell by contacting the enzyme with a peptide fragment derived from an active site of the enzyme under conditions that the fragment is capable of binding to the substrate of the enzyme. This prevents neuronal cell death and alleviates the symptoms of a neurogenerative disorder.
The method provides for an alternate approach to the problem of enzyme inhibition by utilizing a portion of the active site of enzyme itself, instead of using the classical approach that blocks the active site of the enzyme.
Taxonomy
Biological Reagents
Biologically Active Molecules
Molecular & Cellular Neurobiology
Molecular Neurobiology
Neurology
New Drug Discovery & Therapeutics
Ophthalmology
Organic Chemistry
Surgery
Apoptosis/Therapeutic
Drug Design/Therapeutic
Keywords
enzyme, neuronal cell death, neurodegenerative, cysteine proteases, interleukin, active site, pre02 licORpatMinusNYSPI, AAH5set
Licensing Contact
The responsible technology licensing officer is Jerry Kokoshka but for more information on this technology, please contact
stvinfo@columbia.edu
.
Web Links
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Description
Open Link
Patent number: US20050059603
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